Project ImpACT

Important Achievements of Clinical Trials

The aim of Project ImpACT is to identify and develop a comprehensive description of the most important randomized controlled trials (RCTs) performed in the fields of medicine and public health since 1948.

We are defining important broadly. ImpACT Trials are RCTs that have had substantive/significant/important impact on the:

practice of medicine or public health
methods of designing, conducting or analyzing trials
course of subsequent research
understanding of pathophysiology and biology
regulations, law or policy
ethical understanding and conduct of trials

Contribute to the project by nominating a trial.

Click here if you want to view more ImpACT trials. New Profiles were added 9/5/2008.
Study	Discipline	Start Date	Profile	Feedback
Veterans Administration Cooperative Study Group on Antihypertensive Agents. Effects of treatment on morbidity in hypertension.	Cardiology	1964
Coronary Drug Project	Cardiology	1966
Multiple Risk Factor Intervention Trial for Prevention of Coronary Heart Disease	Cardiology	1973
GISSI I	Cardiology	1984
Women's Health Initiative: Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women	Cardiology	1997
University Group Diabetes Program	Endocrinology/Metabolism	1961
Diabetes Control and Complications Trial	Endocrinology/Metabolism	1984
Hepatitis and Rest	Infectious Disease	1951
Salk Vaccine Trial	Infectious Disease	1954
Prevention of Retrolental Fibroplasia in Newborns	Neonatology/perinatology	1953
Influence of the Thermal Environment Upon the Survival of Newly-born Premature Infants	Neonatology/perinatology	1956
Fatal circulatory collapse in premature infants receiving Chloramphenicol	Neonatology/perinatology	1957
Extracorporeal Membrane Oxygenation	Neonatology/perinatology	1986
Randomized trial of DES administration during pregnancy	Obstetrics and Gynecology	1950
A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants	Obstetrics and Gynecology	1969
Collaborative EclampsiaTrial	Obstetrics and Gynecology	1991
Planned caesarean section versus planned vaginal birth for breech presentation at term: a randomised multicentre trial	Obstetrics and Gynecology	1997
Comparison of Radical Mastectomy and Alternative Treatments for Primary Breast Cancer	Oncology	1971
Comparison of Total Mastectomy and Lumpectomy with or without Radiation	Oncology	1976
Diabetic Retinopathy Study	Ophthalmology	1971
Macular Photocoagulation Study	Ophthalmology	1979
Collaborative Ocular Melanoma Study	Ophthalmology	1986

Study	Discipline	Start Date	Profile	Feedback
Efficacy of Esomeprazole for Treatment of Poorly Controlled Asthma	Allergy/Immunology	2004
Efficacy of Human Papillomavirus-16 Vaccine to Prevent Cervical Intraepithelial Neoplasia: A Randomized Controlled Trial	Infectious Disease	1998
Long-Term Effects of Caffeine Therapy for Apnea of Prematurity	Neonatology/perinatology	1999
Surgical vs Nonoperative Treatment for Lumbar Disk Herniation. The Spine Patient Outcomes Research Trial (SPORT): A Randomized Trial.	Surgery	2000